The especially the lungs and the pancreas. Symptoms may

The cystic fibrosis (CF) is a genetic disorder in which there is the accumulation of mucus that clogs some of the organs of the body, especially the lungs and the pancreas. Symptoms may include a salty taste of the skin, a persistent cough, infections frequent pulmonary infections including pneumonia or bronchitis, wheezing or shortness of breath, weak growth or weight loss, many fats and bulky stools, difficulty in evacuating and male infertility. Over time, mucus buildup and infections can lead to permanent lung damage, including the formation of tissue scarring (fibrosis) and cysts in the lungs. CF is caused by several changes ( mutation ) in the gene CFTR and is inherited autosomal recessive.  Treatments depend on symptoms and include respiratory therapy, inhaled medications, pancreatic enzyme supplements, nutritional supplements, and others. Some more recent medications, CFTR modulators have been approved for use in the United States. Ongoing research studies focus on finding the cure for the disease. CauseMutations cause CF at gene CFTR.  Mutations in the CFTR gene result in some cells that cover organs of the body (epithelial cells) such as the inside of the lungs, the digestive tract, the sweat glands, and the genitourinary system, make a protein defective so-called “transmembrane conductance regulator of cystic fibrosis” (CFTR). When the CFTR protein is broken, the epithelial cells cannot regulate the way chloride passes through the layer that covers the cells (cell membranes). This changes the balance between the water and the salt that is needed so that there is a thin layer of liquid and mucus covering the inside of the lungs, the pancreas, and the pathways of other organs. The mucus thickens a lot and can buffer the agencies. Usually, the mucus inside the lungs retains the germs that are then thrown out of the body, but in cystic fibrosis, the thick mucus, along with the bacteria that it has hired, stays inside the lungs, which they end up infecting. In the pancreas, the thick mucus buffers the channels where the enzymes digestive for the intestine that is necessary to digest food. Because of this, the body cannot absorb food, especially fats. Children with CF have problems to gain weight, even if they have a healthy diet and have an excellent fit appetiteHeritageCystic fibrosis (CF) is inherited in an autosomal recessive. This means that to have the disease, a person must have a mutation in both copies of gene CFTR in each cell. Affected people inherit a mutated copy of each parent’s gene, which is called carrier. Carriers of an autosomal recessive disorder typically have no signs or symptoms. In the United States,  all newborns  (screening) are screened for genetic diseases such as CF. If a blood test in the young suspects CF, the doctor makes the diagnosis using a sweating test. This test is the most helpful test for the determination of CF and measures the amount of salt (chloride) in the sweat. To do the sweat test, the person is caused to sweat on a small piece of skin on an arm or leg by rubbing the surface with a chemical that produces sweat and putting on an electrode to give a gentle electric current. This can cause a tingling sensation or a sensation of heat. Sweat is collected on cotton or paper and then analyzed. The sweat test is almost always done twice. High chloride levels confirm a diagnosis of cystic fibrosis